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Scientists have recently discovered and succeeded in synthesizing conolidine, a pure compound that shows promise like a potent analgesic agent with a more favorable safety profile. Although the exact mechanism of action stays elusive, it's currently postulated that conolidine can have severa

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These effects, together with a preceding report showing that a small-molecule ACKR3 agonist CCX771 reveals anxiolytic-like conduct in mice,2 assist the thought of concentrating on ACKR3 as a novel approach to modulate the opioid procedure, which could open new therapeutic avenues for opioid-conn